Invention of spinning wheel.
Chinese Empress Ma is born.
Joan of Arc liberated Orleans, France, from English rule. She is burned at the stake in 1431.
Queen Isabella creates a unified Spain.
Queen Isabella approves the expedition to America led by Christopher Columbus; they land in the Bahamas.
Leonardo da Vinci painted the Mona Lisa.
Queen Mary I tries to reestablish Roman Catholicism in England.
Queen Elizabeth I took the throne in Britain.
Pilgrims and others arrive in Plymouth, Massachusetts, aboard the Mayflower.
Queen Anne's War
Mary Montagu introduced smallpox vaccine to England.